The NYU Food and Microbiome Longitudinal Investigation (FAMiLI) is an ongoing community based prospective cohort study. The cohort is unique for its prospective collection of oral wash and stool samples for microbiome studies in diverse racial and ethnic groups, including Blacks, Asians, Hispanics and Whites. As of Dec., 2020, we have recruited >9000 participants. This study uniquely includes ~40% first generation immigrants. This highly unique resource provides critical population data for health disparity research, including recent seminal findings in minorities on the human microbiome and diet acculturation, quality of life, and obesity. We plan to continue recruitment, to include 14,000 participants, and to continue prospective follow-up during that phase (and thereafter) for cancer and other disease outcomes. The NYU FAMiLI is a unique urban platform with integrated community participation to address priority knowledge gaps regarding the environment, cancer risk and its disparities, in a multi-ethnic cohort, including large numbers of Asian Americans. This research will provide the scientific basis to transform cancer prevention to include personalized and societal-level interventions.